GA4GH Variation Representation Specification

Approved standard


Maximizing the personal, public, research, and clinical value of genomic information will require that clinicians, researchers, and testing laboratories exchange genetic variation data reliably. The Variation Representation Specification (VRS, pronounced “verse”) — written by a partnership among national information resource providers, major public initiatives, and diagnostic testing laboratories — is an open specification to standardize the exchange of variation data.

Here we document the primary contributions of this specification for variation representation:

The machine readable schema definitions and example code are available online at the VRS GitHub repository (

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